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Subject
Liver Diseases -- Path... (63)
Pathology (63)
Liver (63)

Creator
Musc Department of Pat... (63)

Date
1900-1999 (62)
20th C (1)

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The Gordon R. Hennigar Pathology Museum Collection

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Liver: Acute Fulminant Hepatitis
Liver: Acute Fulminant Hepatitis Acute fulminant hepatitis . COMMENT ON SPECIMENS (#25-29): These illustrate the range of changes seen in autopsy livers from patients dying from viral hepatitis (liver disease or complications therefrom): #25=a liver that is bile stained and shows dark areas of necrosis but is not as massively necrotic as #26 and #27 (these two livers probably less than 800-900 gms) and although these two do not now show the usual maroon appearance, there has been a marked loss of hepatocytes. #28 and #29 show pale nodular areas interspersed in liver parenchyma which histologically demonstrates, besides necrosis, scarring or cirrhosis (#28 less, #29 more scarring). The nodular areas actually represent attempts at regeneration of hepatocytes.
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Liver: Acute Hepatic Necrosis
Liver: Acute Hepatic Necrosis Acute hepatic necrosis secondary to occlusion of hepatic veins by renal cell carcinoma and thrombus ). COMMENT: Note thrombosed veins (arrows) and adjacent necrosis (dark areas). Remember tendency of renal cell carcinoma to invade vascular structures (i.e., renal veins to IVC and out hepatic veins).
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Liver: Acute Infectious Hepatitis
Liver: Acute Infectious Hepatitis Acute infectious hepatitis-massive necrosis. COMMENT ON SPECIMENS (#25-29): These illustrate the range of changes seen in autopsy livers from patients dying from viral hepatitis (liver disease or complications therefrom): #25=a liver that is bile stained and shows dark areas of necrosis but is not as massively necrotic as #26 and #27 (these two livers probably less than 800-900 gms) and although these two do not now show the usual maroon appearance, there has been a marked loss of hepatocytes. #28 and #29 show pale nodular areas interspersed in liver parenchyma which histologically demonstrates, besides necrosis, scarring or cirrhosis (#28 less, #29 more scarring). The nodular areas actually represent attempts at regeneration of hepatocytes.
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Liver: Acute Passive Congestion
Liver: Acute Passive Congestion Acute passive congestion of liver. Comment: Darker red areas particularly show a nutmeg pattern
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Liver: Adenocarcinoma of Bile Duct
Liver: Adenocarcinoma of Bile Duct Adenocarcinoma of bile duct. COMMENT: Tumor involves central portion of specimen--obviously in this and above five specimens, the histologic appearance is crucial to the diagnosis
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Liver: Alcoholic Cirrhosis
Liver: Alcoholic Cirrhosis Portal cirrhosis; fatty degeneration. COMMENT: Specimens 13-22 are all examples of cirrhosis associated with alcoholism (Laennec's, portal, nutritional, alcoholic)--note that the specimens have a micronodular pattern in general with a generally uniform appearance to the nodules; however, note that some of the livers have nodules of up to about 1 cm. (see note below) and that there may be some variability in nodule size within one specimen. Intervening parenchyma is composed of fibrous septae. Also note that the remaining nodular liver parenchyma is quite pale or yellow = fatty change associated with continued alcohol abuse. Picture corresponding microscopic picture in your mind's eye of fatty change and cirrhosis (remember the definition of cirrhosis). Specimen #22 indicates that microscopically there is necrosis of hepatocytes with an inflammatory response = this is not evident grossly in this specimen. In this series, the small firm livers are good examples of end stage nutritional or alcoholic cirrhosis. NOTE: Although Robbins says that micronodular cirrhosis has nodules of up to 1 cm. in diameter, Dr. Hennigar's measurement of 3mm. and below is more characteristic.
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Liver: Alcoholic Cirrhosis
Liver: Alcoholic Cirrhosis Alcoholic cirrhosis . COMMENT: Specimens 13-22 are all examples of cirrhosis associated with alcoholism (Laennec's, portal, nutritional, alcoholic)--note that the specimens have a micronodular pattern in general with a generally uniform appearance to the nodules; however, note that some of the livers have nodules of up to about 1 cm. (see note below) and that there may be some variability in nodule size within one specimen. Intervening parenchyma is composed of fibrous septae. Also note that the remaining nodular liver parenchyma is quite pale or yellow = fatty change associated with continued alcohol abuse. Picture corresponding microscopic picture in your mind's eye of fatty change and cirrhosis (remember the definition of cirrhosis). Specimen #22 indicates that microscopically there is necrosis of hepatocytes with an inflammatory response = this is not evident grossly in this specimen. In this series, the small firm livers are good examples of end stage nutritional or alcoholic cirrhosis. NOTE: Although Robbins says that micronodular cirrhosis has nodules of up to 1 cm. in diameter, Dr. Hennigar's measurement of 3mm. and below is more characteristic.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Severe fatty metamorphosis of liver (No number). Comment on L-10 through L-12: Livers are pale, enlarged with ""rolled"" edges--one specimen (L-12) has been stained with Oil Red O to demonstrate the fat present in the tissue.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Alcoholic fatty liver.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Marked fatty change of liver (alcoholism). Comment on L-10 through L-12: Livers are pale, enlarged with ""rolled"" edges--one specimen (L-12) has been stained with Oil Red O to demonstrate the fat present in the tissue.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Fatty liver of alcoholism . Comment on L-10 through L-12: Livers are pale, enlarged with ""rolled"" edges--one specimen (L-12) has been stained with Oil Red O to demonstrate the fat present in the tissue.
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Liver: Amyloidosis
Liver: Amyloidosis Amyloidosis of liver. COMMENT: Liver is enlarged, otherwise not very remarkable to the naked eye.
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Liver: Atherosclerotic Aneurysm of Hepatic Artery
Liver: Atherosclerotic Aneurysm of Hepatic Artery Atherosclerotic aneurysm of hepatic artery. COMMENT: Unusual manifestation of atherosclerosis
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Liver: Biliary Atresia
Liver: Biliary Atresia Biliary atresia in 3 y.o. with biliary cirrhosis, esophageal varices and congested spleen. COMMENT: (#36-#37): Biliary cirrhosis--two examples--of the secondary type, i.e., secondary to atresia (or obstruction) of extrahepatic or intrahepatic bile ducts. Both are examples of micronodular cirrhosis. In the first, ectasia of intrahepatic bile ducts can be appreciated. In the second, appreciate the blood-filled submucosal esophageal varices and the enormous spleen with focal subcapsular infarcts (at top) (compare size of spleen with esophagus to appreciate the splenomegaly).
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Liver: Biliary Cirrhosis
Liver: Biliary Cirrhosis Biliary cirrhosis secondary to common bile duct atresia. COMMENT: (#36-#37): Biliary cirrhosis--two examples--of the secondary type, i.e., secondary to atresia (or obstruction) of extrahepatic or intrahepatic bile ducts. Both are examples of micronodular cirrhosis. In the first, ectasia of intrahepatic bile ducts can be appreciated. In the second, appreciate the blood-filled submucosal esophageal varices and the enormous spleen with focal subcapsular infarcts (at top) (compare size of spleen with esophagus to appreciate the splenomegaly).
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Liver: Cardiac Cirrhosis
Liver: Cardiac Cirrhosis Cardiac cirrhosis. COMMENT: You would expect a centrilobular necrosis and fibrosis in cirrhosis resulting from right-sided heart failure. A resulting fine cirrhosis is present usually as in most of this specimen; however, there are a few areas of broader scars in the center of the specimen.
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Liver: Centrilobular Necrosis
Liver: Centrilobular Necrosis Massive centrilobular necrosis secondary to heart disease
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Liver: Cholangiocarcinoma
Liver: Cholangiocarcinoma Cholangiocarcinoma. COMMENT: Diffuse involvement by tumor (Green = ""normal"" liver)--small areas of infarct also present (arrows)
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Liver: Cholangiocarcinoma
Liver: Cholangiocarcinoma Cholangiocarcinoma and metastatic oat cell carcinoma in liver. COMMENT: Central carved-out area represents focus of cholangiocarcinoma; nodular areas=metastatic oat cell (lung) tumor (A81-512)
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Liver: Chronic Myelogenous Leukemia
Liver: Chronic Myelogenous Leukemia Chronic myelogenous leukemia with myelofibrosis (of bone marrow)--chronic lymphocytic leukemia usually results in more striking hepatomegaly than CML but this liver is most remarkably enlarged, although no nodular leukemic infiltrates can be seen. Myelofibrosis (fibrosis of bone marrow) may have contributed to the hepatosplenomegaly if hematopoiesis was present in the liver