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Subject
Liver Diseases -- Path... (28)
Pathology (28)
Liver (28)

Creator
Musc Department of Pat... (28)

Date
1900-1999 (27)
20th C (1)

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The Gordon R. Hennigar Pathology Museum Collection

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1.
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Liver: Multiple Adenomas
Liver: Multiple Adenomas Multiple liver cell adenomas. COMMENT(#49 & #50): Good examples of multiple adenomas; areas of infarction/hemorrhage often found (remember microscopic characteristics).
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Liver: Hepatocellular Carcinoma, Laennec's Cirrhosis
Liver: Hepatocellular Carcinoma, Laennec's Cirrhosis Hepatocellular carcinoma in Laennec's cirrhosis. COMMENT: Although more likely to occur in postnecrotic cirrhosis, can see this in Laennec's cirrhosis (mass in upper right = tumor)
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Liver: Primary Hepatoma--Cholangiocarcinoma
Liver: Primary Hepatoma--Cholangiocarcinoma Primary hepatoma--cholangiocarcinoma. COMMENT: Good portion of specimen occupied by solid white tumor (arrow) infiltrating liver
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Liver: Cholangiocarcinoma
Liver: Cholangiocarcinoma Cholangiocarcinoma. COMMENT: Diffuse involvement by tumor (Green = ""normal"" liver)--small areas of infarct also present (arrows)
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Liver: Cholangiocarcinoma
Liver: Cholangiocarcinoma Cholangiocarcinoma and metastatic oat cell carcinoma in liver. COMMENT: Central carved-out area represents focus of cholangiocarcinoma; nodular areas=metastatic oat cell (lung) tumor (A81-512)
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Liver: Adenocarcinoma of Bile Duct
Liver: Adenocarcinoma of Bile Duct Adenocarcinoma of bile duct. COMMENT: Tumor involves central portion of specimen--obviously in this and above five specimens, the histologic appearance is crucial to the diagnosis
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Liver: Hepatoblastoma
Liver: Hepatoblastoma Hepatoblastoma (mixed type) . COMMENT: Rare malignant tumor of liver in infancy and childhood with histologic picture consisting of cells resembling fetal liver cells, undifferentiated cells or occasionally admixed with other connective tissue elements. Prognosis usually better than hepatocellular carcinoma
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Liver: Metastatic Oat Cell Carcinoma of Lung
Liver: Metastatic Oat Cell Carcinoma of Lung Oat cell carcinoma of lung metastatic to liver. COMMENT (#60-64): Metastatic tumors in liver characteristically have central necrosis (umbilicated appearance through the capsule) due to outgrowth of blood/nutrient supply--other than this, variations in appearance may reflect origin of tumor i.e., the melanoma is represented by both pigmented and non-pigmented (amelanotic) metastases; choriocarcinoma typically is hemorrhagic. The cholelithiasis in #64 is unrelated to metastatic tumor)
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Liver: Metastatic Breast Carcinoma
Liver: Metastatic Breast Carcinoma Metastatic breast carcinoma
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Liver: Metastatic Ovarian Carcinoid
Liver: Metastatic Ovarian Carcinoid Ovarian carcinoid metastatic to liver
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Liver: Metastatic Malignant Melanoma
Liver: Metastatic Malignant Melanoma Malignant melanoma metastatic to liver and spleen (no number). COMMENT (#60-64): Metastatic tumors in liver characteristically have central necrosis (umbilicated appearance through the capsule) due to outgrowth of blood/nutrient supply--other than this, variations in appearance may reflect origin of tumor i.e., the melanoma is represented by both pigmented and non-pigmented (amelanotic) metastases; choriocarcinoma typically is hemorrhagic. The cholelithiasis in #64 is unrelated to metastatic tumor)
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Liver: Metastatic Choriocarcinoma
Liver: Metastatic Choriocarcinoma Metastatic choriocarcinoma to liver from testis. COMMENT (#60-64): Metastatic tumors in liver characteristically have central necrosis (umbilicated appearance through the capsule) due to outgrowth of blood/nutrient supply--other than this, variations in appearance may reflect origin of tumor i.e., the melanoma is represented by both pigmented and non-pigmented (amelanotic) metastases; choriocarcinoma typically is hemorrhagic. The cholelithiasis in #64 is unrelated to metastatic tumor)
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Liver: Metastatic Choriocarcinoma
Liver: Metastatic Choriocarcinoma Metastatic choriocarcinoma; multifaceted pigment stones in gallbladder. COMMENT (#60-64): Metastatic tumors in liver characteristically have central necrosis (umbilicated appearance through the capsule) due to outgrowth of blood/nutrient supply--other than this, variations in appearance may reflect origin of tumor i.e., the melanoma is represented by both pigmented and non-pigmented (amelanotic) metastases; choriocarcinoma typically is hemorrhagic. The cholelithiasis in #64 is unrelated to metastatic tumor)
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Liver: Laceration
Liver: Laceration Laceration of liver
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Liver: Multiple Infarction, Ischemic Heart Disease
Liver: Multiple Infarction, Ischemic Heart Disease Multiple infarction of liver--ischemic heart disease. Comment: Multifocal areas of infarction are present--easiest to see are white, sharply demarcated, with irregular borders.
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Liver: Biliary Atresia
Liver: Biliary Atresia Biliary atresia in 3 y.o. with biliary cirrhosis, esophageal varices and congested spleen. COMMENT: (#36-#37): Biliary cirrhosis--two examples--of the secondary type, i.e., secondary to atresia (or obstruction) of extrahepatic or intrahepatic bile ducts. Both are examples of micronodular cirrhosis. In the first, ectasia of intrahepatic bile ducts can be appreciated. In the second, appreciate the blood-filled submucosal esophageal varices and the enormous spleen with focal subcapsular infarcts (at top) (compare size of spleen with esophagus to appreciate the splenomegaly).
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Liver: Cirrhosis
Liver: Cirrhosis Finely and coarsely nodular cirrhosis of liver (mucoviscidosis sequelae). COMMENT (#40-#41): Although a finely nodular biliary cirrhosis is described, one can also see a coarsely nodular (macronodular) pattern in the livers of longstanding cystic fibrosis
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Liver: Nodular Hyperplasia
Liver: Nodular Hyperplasia Nodular hyperplasia of liver. COMMENT: #46 and #48 have well developed scars in the presence of nodular liver tissue, these being the gross characteristics of this lesion (review microscopic characteristics).
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Liver: Thorotrast Cirrhosis
Liver: Thorotrast Cirrhosis Thorotrast cirrhosis; hemangioendothelial sarcoma. COMMENT: Tumor nodules throughout-black or dark appearance in part due to thorotrast (No number)
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Liver: Chronic Myelogenous Leukemia
Liver: Chronic Myelogenous Leukemia Chronic myelogenous leukemia with myelofibrosis (of bone marrow)--chronic lymphocytic leukemia usually results in more striking hepatomegaly than CML but this liver is most remarkably enlarged, although no nodular leukemic infiltrates can be seen. Myelofibrosis (fibrosis of bone marrow) may have contributed to the hepatosplenomegaly if hematopoiesis was present in the liver