Phase II studies in oncology have evolved over the previous several decades. Currently, the number of drugs in phase II development has increased, and patient eligibility has narrowed due to targeted agents, competing trials and curative therapies in the first-line setting. As a result of these changes, more attention needs to be focused toward conducting more efficient phase II trials. Given the increased difficulty in accruing patients to phase II studies and the ethical concern of treating patients with agents that are ineffective, there is significant motivation to stop a single arm trial early when the investigational agent shows evidence of a low response rate.
Abstract: We develop a new Bayesian two-stage space-time mixture model to investigate the effects of
air pollution on asthma. The two-stage mixture model proposed allows for the identification
of temporal latent structure as well as the estimation of the effects of covariates on health
outcomes. In the paper, we also consider spatial misalignment of exposure and health data.
A simulation study is conducted to assess the performance of the 2-stage mixture model.
We apply our statistical framework to a county-level ambulatory care asthma data set in the
US state of Georgia for the years 1999-2008.
Key words: Space-time mixture model; air pollution; covariate adjustment; asthma;
Abstract: Health outcomes are linked to air pollution, demographic, or socioeconomic factors which vary across space and time. Thus, it is often found that relative risks in spatial health data have locally different patterns. In such cases, latent modeling is useful in the disaggregation of risk proﬁles. In particular, spatial-temporal mixture models can help to isolate spatial clusters each of which has a homogeneous temporal pattern in relative risks. Mixture models are assumed as they have various weight structures and considered in two situations: the number of underlying components is known or unknown. In this paper, we compare spatial-temporal mixture models with different weight structures in both situations. For comparison, we propose a set of spatial cluster detection diagnostics which are based on the posterior distribution of weights. We also develop new accuracy measures to assess the recovery of true relative risk. Based on the simulation study, we examine the performance of various spatial-temporal mixture models in terms of proposed methods and goodness-of-ﬁt measures. We examine two real data sets: low birth weight data and chronic obstructive pulmonary disease data.
Abstract: Background: Novel statistical methods are constantly being developed within the context of biomedical research; however, the rate of diffusion of this knowledge into the field of general / internal medicine is unclear. This study highlights the statistical journal articles, the statistical journals, and the statistical methods that appear to be having the most direct impact on research in the field of general / internal medicine. Methods: Descriptive techniques, including analyses of articles’ keywords and controlled vocabulary terms, were used to characterize the articles published in statistics and probability journals that were subsequently referenced within general / internal medicine journal articles during a recent 10-year period (2000-2009). Results: From the 45 statistics and probability journals of interest, a total of 597 unique articles were identified as being cited by 900 (out of a total of about 10,501) unique general / internal medicine journal articles. The most frequently cited statistical topics included general/other statistical methods, followed by epidemiologic methods, randomized trials, generalized linear models, meta-analysis, and missing data. Conclusion: As statisticians continue to develop and refine techniques, the promotion and adoption of these methods should also be addressed so that their efforts spent in developing the methods are not done in vain.
Abstract: Surveillance systems are often focused on more than one disease within a predefined area. On those occasions when outbreaks of disease are likely to be
correlated, the use of multivariate surveillance techniques integrating information from multiple diseases allows us to improve the sensitivity and timeliness of outbreak detection. In this paper, we present an extension of the surveillance conditional predictive ordinate to monitor multivariate spatial disease data. The proposed surveillance technique, which is defined for each small area and time period as the conditional predictive distribution of those counts of disease higher
than expected given the data observed up to the previous time period, alerts us to both small areas of increased disease incidence and the diseases causing the
alarm within each area. We investigate its performance within the framework of Bayesian hierarchical Poisson models using a simulation study. An application
to diseases of the respiratory system in South Carolina is finally presented. Keywords: disease surveillance; multiple diseases; Shared component model; conditional predictive ordinate