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Creator
Musc Department of Pat... (35)

Date
1900-1999 (35)

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The Gordon R. Hennigar Pathology Museum Collection

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Liver: Multiple Adenomas
Liver: Multiple Adenomas Multiple liver cell adenomas . COMMENT(#49 & #50): Good examples of multiple adenomas; areas of infarction/hemorrhage often found (remember microscopic characteristics).
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Liver: Acute Passive Congestion
Liver: Acute Passive Congestion Acute passive congestion of liver. Comment: Darker red areas particularly show a nutmeg pattern
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Liver: Necrosis
Liver: Necrosis Massive necrosis of the liver, possibly to halothane.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Marked fatty change of liver (alcoholism). Comment on L-10 through L-12: Livers are pale, enlarged with ""rolled"" edges--one specimen (L-12) has been stained with Oil Red O to demonstrate the fat present in the tissue.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Fatty liver of alcoholism . Comment on L-10 through L-12: Livers are pale, enlarged with ""rolled"" edges--one specimen (L-12) has been stained with Oil Red O to demonstrate the fat present in the tissue.
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Liver: Amyloidosis
Liver: Amyloidosis Amyloidosis of liver. COMMENT: Liver is enlarged, otherwise not very remarkable to the naked eye.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Alcoholic fatty liver.
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Liver: Polyarteritis Nodosa, Infarction
Liver: Polyarteritis Nodosa, Infarction Polyarteritis nodosa with liver and kidney infarcts. Comment: Almost entire left lobe is infarcted--arrow points to thrombosed hepatic artery branch; many arteries (arrows) near the corticomedullary junctions of kidney (probably arcuate arteries) have abnormally thick walls and are thrombosed--infarcts can be seen (arrows).
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Liver: Cirrhosis of Liver in Cystic Fibrosis
Liver: Cirrhosis of Liver in Cystic Fibrosis Cirrhosis of liver in cystic fibrosis. COMMENT (#40-#41): Although a finely nodular biliary cirrhosis is described, one can also see a coarsely nodular (macronodular) pattern in the livers of longstanding cystic fibrosis.
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Liver: Polycystic
Liver: Polycystic Polycystic liver in Potter Type III polycystic kidney disease
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Liver: Hamartoma
Liver: Hamartoma Hamartoma of liver. COMMENT: Only a small rim of normal liver is present at the left
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Liver: Nodular Hyperplasia
Liver: Nodular Hyperplasia Nodular hyperplasia of liver. COMMENT: #46 and #48 have well developed scars in the presence of nodular liver tissue, these being the gross characteristics of this lesion (review microscopic characteristics).
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Liver: Laennec's Cirrhosis
Liver: Laennec's Cirrhosis Laennec's cirrhosis and fatty liver. COMMENT: Specimens 13-22 are all examples of cirrhosis associated with alcoholism (Laennec's, portal, nutritional, alcoholic)--note that the specimens have a micronodular pattern in general with a generally uniform appearance to the nodules; however, note that some of the livers have nodules of up to about 1 cm. (see note below) and that there may be some variability in nodule size within one specimen. Intervening parenchyma is composed of fibrous septae. Also note that the remaining nodular liver parenchyma is quite pale or yellow = fatty change associated with continued alcohol abuse. Picture corresponding microscopic picture in your mind's eye of fatty change and cirrhosis (remember the definition of cirrhosis). Specimen #22 indicates that microscopically there is necrosis of hepatocytes with an inflammatory response = this is not evident grossly in this specimen. In this series, the small firm livers are good examples of end stage nutritional or alcoholic cirrhosis. NOTE: Although Robbins says that micronodular cirrhosis has nodules of up to 1 cm. in diameter, Dr. Hennigar's measurement of 3mm. and below is more characteristic.
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Liver: Post-Necrotic Cirrhosis--Hepatic B Viruses
Liver: Post-Necrotic Cirrhosis--Hepatic B Viruses Post-necrotic cirrhosis--Hepatic B viruses. COMMENT ON SPECIMENS (#25-29): These illustrate the range of changes seen in autopsy livers from patients dying from viral hepatitis (liver disease or complications therefrom): #25=a liver that is bile stained and shows dark areas of necrosis but is not as massively necrotic as #26 and #27 (these two livers probably less than 800-900 gms) and although these two do not now show the usual maroon appearance, there has been a marked loss of hepatocytes. #28 and #29 show pale nodular areas interspersed in liver parenchyma which histologically demonstrates, besides necrosis, scarring or cirrhosis (#28 less, #29 more scarring). The nodular areas actually represent attempts at regeneration of hepatocytes.
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Liver: Primary Hemochromatosis
Liver: Primary Hemochromatosis Primary hemochromatosis. COMMENT: Characteristic picture of pigment cirrhosis of finely nodular brown liver.
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Liver: Laennec's Cirrhosis
Liver: Laennec's Cirrhosis Laennec's cirrhosis. COMMENT: Specimens 13-22 are all examples of cirrhosis associated with alcoholism (Laennec's, portal, nutritional, alcoholic)--note that the specimens have a micronodular pattern in general with a generally uniform appearance to the nodules; however, note that some of the livers have nodules of up to about 1 cm. (see note below) and that there may be some variability in nodule size within one specimen. Intervening parenchyma is composed of fibrous septae. Also note that the remaining nodular liver parenchyma is quite pale or yellow = fatty change associated with continued alcohol abuse. Picture corresponding microscopic picture in your mind's eye of fatty change and cirrhosis (remember the definition of cirrhosis). Specimen #22 indicates that microscopically there is necrosis of hepatocytes with an inflammatory response = this is not evident grossly in this specimen. In this series, the small firm livers are good examples of end stage nutritional or alcoholic cirrhosis. NOTE: Although Robbins says that micronodular cirrhosis has nodules of up to 1 cm. in diameter, Dr. Hennigar's measurement of 3mm. and below is more characteristic.
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Liver: Hepatitis
Liver: Hepatitis INH hepatitis with massive necrosis. COMMENT: Looks just like the massive necrosis of fulminant viral hepatitis (decrease in liver size, shrunken capsule, vascular structures close together, purple red, soft, flabby).
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Liver: Centrilobular Necrosis
Liver: Centrilobular Necrosis Massive centrilobular necrosis secondary to heart disease
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Liver: Acute Infectious Hepatitis
Liver: Acute Infectious Hepatitis Acute infectious hepatitis-massive necrosis. COMMENT ON SPECIMENS (#25-29): These illustrate the range of changes seen in autopsy livers from patients dying from viral hepatitis (liver disease or complications therefrom): #25=a liver that is bile stained and shows dark areas of necrosis but is not as massively necrotic as #26 and #27 (these two livers probably less than 800-900 gms) and although these two do not now show the usual maroon appearance, there has been a marked loss of hepatocytes. #28 and #29 show pale nodular areas interspersed in liver parenchyma which histologically demonstrates, besides necrosis, scarring or cirrhosis (#28 less, #29 more scarring). The nodular areas actually represent attempts at regeneration of hepatocytes.
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Liver: Viral Hepatitis
Liver: Viral Hepatitis Viral hepatitis. COMMENT ON SPECIMENS (#25-29): These illustrate the range of changes seen in autopsy livers from patients dying from viral hepatitis (liver disease or complications therefrom): #25=a liver that is bile stained and shows dark areas of necrosis but is not as massively necrotic as #26 and #27 (these two livers probably less than 800-900 gms) and although these two do not now show the usual maroon appearance, there has been a marked loss of hepatocytes. #28 and #29 show pale nodular areas interspersed in liver parenchyma which histologically demonstrates, besides necrosis, scarring or cirrhosis (#28 less, #29 more scarring). The nodular areas actually represent attempts at regeneration of hepatocytes.