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The Gordon R. Hennigar Pathology Museum Collection

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41.
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Liver: Halothane Hepatitis
Liver: Halothane Hepatitis Halothane hepatitis. Comment: (Both this and above specimen have bile stained fluid in the preservative) Dark areas probably represent the areas of necrosis; some of these areas interconnect; remaining cells may contain some fat.
42.
Liver: Gunshot Wound with Hemorrhage and Necrosis
Liver: Gunshot Wound with Hemorrhage and Necrosis GSW of liver with hemorrhage and necrosis
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Liver: Nodular Hyperplasia
Liver: Nodular Hyperplasia Focal nodular hyperplasia of liver.COMMENT: #46 and #48 have well developed scars in the presence of nodular liver tissue, these being the gross characteristics of this lesion (review microscopic characteristics).
44.
Liver: Cirrhosis
Liver: Cirrhosis Finely and coarsely nodular cirrhosis of liver (mucoviscidosis sequelae). COMMENT (#40-#41): Although a finely nodular biliary cirrhosis is described, one can also see a coarsely nodular (macronodular) pattern in the livers of longstanding cystic fibrosis
45.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Fatty liver of alcoholism . Comment on L-10 through L-12: Livers are pale, enlarged with ""rolled"" edges--one specimen (L-12) has been stained with Oil Red O to demonstrate the fat present in the tissue.
46.
Liver: Fatal Intraperitoneal Hemorrhage
Liver: Fatal Intraperitoneal Hemorrhage Fatal intraperitoneal hemorrhage following needle biopsy of normal liver. Comment: Note needle tract and subcapsular hemorrhage.
47.
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Liver: Cirrhosis of Liver in Cystic Fibrosis
Liver: Cirrhosis of Liver in Cystic Fibrosis Cirrhosis of liver in cystic fibrosis. COMMENT (#40-#41): Although a finely nodular biliary cirrhosis is described, one can also see a coarsely nodular (macronodular) pattern in the livers of longstanding cystic fibrosis.
48.
Liver: Chronic Myelogenous Leukemia
Liver: Chronic Myelogenous Leukemia Chronic myelogenous leukemia with myelofibrosis (of bone marrow)--chronic lymphocytic leukemia usually results in more striking hepatomegaly than CML but this liver is most remarkably enlarged, although no nodular leukemic infiltrates can be seen. Myelofibrosis (fibrosis of bone marrow) may have contributed to the hepatosplenomegaly if hematopoiesis was present in the liver
49.
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Liver: Cholangiocarcinoma
Liver: Cholangiocarcinoma Cholangiocarcinoma. COMMENT: Diffuse involvement by tumor (Green = ""normal"" liver)--small areas of infarct also present (arrows)
50.
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Liver: Cholangiocarcinoma
Liver: Cholangiocarcinoma Cholangiocarcinoma and metastatic oat cell carcinoma in liver. COMMENT: Central carved-out area represents focus of cholangiocarcinoma; nodular areas=metastatic oat cell (lung) tumor (A81-512)
51.
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Liver: Cardiac Cirrhosis
Liver: Cardiac Cirrhosis Cardiac cirrhosis. COMMENT: You would expect a centrilobular necrosis and fibrosis in cirrhosis resulting from right-sided heart failure. A resulting fine cirrhosis is present usually as in most of this specimen; however, there are a few areas of broader scars in the center of the specimen.
52.
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Liver: Biliary Cirrhosis
Liver: Biliary Cirrhosis Biliary cirrhosis secondary to common bile duct atresia. COMMENT: (#36-#37): Biliary cirrhosis--two examples--of the secondary type, i.e., secondary to atresia (or obstruction) of extrahepatic or intrahepatic bile ducts. Both are examples of micronodular cirrhosis. In the first, ectasia of intrahepatic bile ducts can be appreciated. In the second, appreciate the blood-filled submucosal esophageal varices and the enormous spleen with focal subcapsular infarcts (at top) (compare size of spleen with esophagus to appreciate the splenomegaly).
53.
Liver: Biliary Atresia
Liver: Biliary Atresia Biliary atresia in 3 y.o. with biliary cirrhosis, esophageal varices and congested spleen. COMMENT: (#36-#37): Biliary cirrhosis--two examples--of the secondary type, i.e., secondary to atresia (or obstruction) of extrahepatic or intrahepatic bile ducts. Both are examples of micronodular cirrhosis. In the first, ectasia of intrahepatic bile ducts can be appreciated. In the second, appreciate the blood-filled submucosal esophageal varices and the enormous spleen with focal subcapsular infarcts (at top) (compare size of spleen with esophagus to appreciate the splenomegaly).
54.
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Liver: Atherosclerotic Aneurysm of Hepatic Artery
Liver: Atherosclerotic Aneurysm of Hepatic Artery Atherosclerotic aneurysm of hepatic artery. COMMENT: Unusual manifestation of atherosclerosis
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Liver: Amyloidosis
Liver: Amyloidosis Amyloidosis of liver. COMMENT: Liver is enlarged, otherwise not very remarkable to the naked eye.
56.
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Liver:: Alpha-1-Antitrypsin Deficiency.
Liver:: Alpha-1-Antitrypsin Deficiency. Alpha-1-antitrypsin deficiency. COMMENT: Bile stasis and a micronodular cirrhosis are seen in this example of enzyme deficiency disease. Can also result in a macronodular cirrhosis
57.
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Liver: Alcoholic Fatty Liver
Liver: Alcoholic Fatty Liver Alcoholic fatty liver.
58.
Liver: Alcoholic Cirrhosis
Liver: Alcoholic Cirrhosis Alcoholic cirrhosis . COMMENT: Specimens 13-22 are all examples of cirrhosis associated with alcoholism (Laennec's, portal, nutritional, alcoholic)--note that the specimens have a micronodular pattern in general with a generally uniform appearance to the nodules; however, note that some of the livers have nodules of up to about 1 cm. (see note below) and that there may be some variability in nodule size within one specimen. Intervening parenchyma is composed of fibrous septae. Also note that the remaining nodular liver parenchyma is quite pale or yellow = fatty change associated with continued alcohol abuse. Picture corresponding microscopic picture in your mind's eye of fatty change and cirrhosis (remember the definition of cirrhosis). Specimen #22 indicates that microscopically there is necrosis of hepatocytes with an inflammatory response = this is not evident grossly in this specimen. In this series, the small firm livers are good examples of end stage nutritional or alcoholic cirrhosis. NOTE: Although Robbins says that micronodular cirrhosis has nodules of up to 1 cm. in diameter, Dr. Hennigar's measurement of 3mm. and below is more characteristic.
59.
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Liver: Adenocarcinoma of Bile Duct
Liver: Adenocarcinoma of Bile Duct Adenocarcinoma of bile duct. COMMENT: Tumor involves central portion of specimen--obviously in this and above five specimens, the histologic appearance is crucial to the diagnosis
60.
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Liver: Acute Passive Congestion
Liver: Acute Passive Congestion Acute passive congestion of liver. Comment: Darker red areas particularly show a nutmeg pattern
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